Rexetin: instructions for use, reviews of patients and doctors, analogues

rexetineIn the practice of modern specialists, the use of antidepressant Rexetine. It is prescribed to patients with prolonged depression, with frequent alarm conditions, stress and other mental disorders.

The complex therapeutic effect of an antidepressant effectively helps people who have fallen into an unpleasant life situation.


  • Release form and composition
  • Pharmacological profile
  • Indications and contraindications for use
  • Dosage and administration
  • Overdose incidents
  • Adverse reactions
  • special instructions
  • Drug interactions
  • Real experience
  • Purchase and selection of analogues

Release form and composition

Rexetine is available in the form of round-shaped tablets, convex on both sides, having a white color, coated in the form of

paroxetine hydrochloride hemihydrate

The formula of paroxetine hydrochloride hemihydrate

film. On one side there is an engraving - "X 20", the diameter is 1.1 cm.

Each tablet contains the active component of paroxetine hydrochloride hemihydrate in the amount of 22, 76 mg, which is equivalent to 20 mg. paroxetine. Auxiliary components include the following:

  • calcium phosphate dihydrate;
  • polysorbate - 80;
  • sodium glycolate;
  • macrogols;
  • titanium dioxide;
  • magnesium stearate;
  • giprommeloza.

A medicine is also produced, which contains the active substance in the amount of 30 mg, engraving of such tablets - "X 30". The high content of the active component is manifested in a more pronounced effect on the body.

The packaging is cardboard, has a rectangular white color. The package is one blister, which contains 30 tablets.

Pharmacological profile

Rexetine - selective serotonin reuptake inhibitorIt has a powerful anti-anxiety effect. The main active ingredient of the drug is paroxetine - a substance having a bicyclic structure suspends the activity of the vesicles aimed at replenishing the reserves of serotonin, concentrating its accumulation in the synaptic cleft. At the same time, the active substance stimulates the reuptake of norepinephrine and dopamine.

After entering the gastrointestinal tract, the stage of absorption into the blood of the active substances of the drug and their distribution throughout the body begins. It is worth noting that the effect of Rexetin does not change depending on eating or drinking.

The next stage is the distribution, it occurs due to the connection of the majority of paroxetine with protein compounds found in the blood. To act on the body at a stable level, the active ingredients of Rexetin begin approximately two weeks after the start of treatment and then the therapeutic effect remains at the same level until the end therapy.

The final process is metabolism - the splitting of inactive components by the liver cells and removal from the body. This occurs by urination about two days after ingestion.

The drug has an effect on the cells of the central nervous system (CNS). Making a reverse seizure of serotonin, blocking its exit from the middle part of the synapse - the place of communication between the neurons of the brain. The seizure of norepinephrine and dopamine remains virtually unchanged. It also has an anti-anxiety effect and activates mental activity.

Indications and contraindications for use

Rexetine is prescribed for the following indications:

  • obsessive compulsive disorderaccompanied by obsessive ideas;Fear of society
  • generalized anxiety disordercharacterized by anxiety and panic attacks of fear;
  • social phobia and other phobic disorders;
  • state of stress associated with suffering any injuries;
  • acute reaction to a stressful situation;
  • prolonged depression caused by various factors, including a pathological change in the cerebral cortex;
  • agoraphobia - fear of crowds, and other fears and panic disorders.

The drug is also prescribed for prophylactic purposes in order to relieve the recurrence of depressive and anxiety disorders.


  • individual intolerance to the components of the drug;
  • pregnancy during the whole period;
  • breast-feeding;
  • children up to 18 years;
  • the use of monoamine oxidase inhibitors, as well as the period after discontinuation of their administration for at least 14 days;
  • prostatic hyperplasia;
  • diseases of the heart and blood vessels;
  • epilepsy;
  • glaucoma;
  • elderly age.

Pregnant woman drinking waterDuring pregnancy, the use of the drug is allowed only in extreme cases associated with vital signs.

Since uncontrolled intake can cause complications and even lead to premature labor.

If necessary, the appointment of the drug during lactation, the doctor should decide on the abolition of breastfeeding.

Completely excluded the appointment of the drug to children and adolescents under the age of 18 years.

For women undergoing Rexetine, it is recommended to use contraception during the entire dose and for some time after the end of the course.

Dosage and administration

During the course of treatment with Rexetin, you must adhere to the following instructions:Depression medication

  • taking pills is better in the morning during the meal;
  • the pill must be swallowed whole, without chewing;
  • the number of receptions - 1 time per day;
  • the doctor, after examining the patient after three weeks, adjusts the dosage.

Daily dosage:

  • at depressive disorders One tablet is prescribed (X 20), but not more than 50 mg per day;
  • social phobia - initially 20 mg., In the absence of a result, an increase in dosage to 50 per day;
  • panic disorders - 10 mg., Gradually bringing the dose to 40;
  • obsessive-compulsive disorder - 20 mg., The maximum dosage, if necessary, 60 mg.
  • generalized anxiety disorder - 20-50 mg per day.

After the disappearance of the symptoms of mental disorders, it is necessary to continue taking the medication for prophylactic purposes in order to avoid recurrence.

The course of treatment lasts from 4 to 6 months, but for disorders associated with bouts of fear and panic, prolongation of therapy is possible. The course should be completed gradually, avoiding abrupt discontinuation of SSRIs.

Overdose incidents

The use of an antidepressant is well tolerated by patients, the drug is completely safe while respecting the prescribed dose. Signs of overdose begin to be observed after a single dose of 2000 mg., Or when the drug is combined with alcohol and other drugs.

Signs of overdose medication:

  • nausea and vomiting;Nausea over toilet
  • convulsions and trembling limbs;
  • feeling of dry mouth;
  • drowsiness;
  • dizziness;
  • redness of the face and skin of the upper parts of the body;
  • dilated pupils and agitated state.

The specific antidote is absent. In such cases, the following events should be held:

  • control of vital functions;
  • release of airways;
  • gastric lavage;
  • induction of vomiting;
  • oxygen therapy;
  • the use of activated carbon every 4 hours for two days.

Patients are advised to strictly follow the prescriptions of the doctor and not to self-medicate.

Adverse reactions

When you receive Rexetin may experience the following side effects:

  • nausea, constipation or diarrhea, loss of appetite;
  • abnormal liver function;
  • drowsiness, trembling in limbs, fatigue and feeling tiredinsomnia headacheanxiety, alarm condition, dizziness, low concentration;
  • also increased sweating and a feeling of dry mouth;
  • vision loss, pupil dilation, glaucoma attacks are rarely observed;
  • heart palpitations, changes in heart rhythms, changes in blood pressure, fainting;
  • the deterioration of ejaculation in men, decreased sexual desire, difficulty urinating;
  • sometimes there was an increase in sodium in the blood plasma, accompanied by the formation of peripheral edema, signs of epilepsy;
  • skin redness, subcutaneous bleeding, swelling of the face and extremities, allergic dermatitis, itching.

During therapy, the weight may begin to decrease, symptoms of acute respiratory viral infections may appear, an increase in bleeding is observed.

Abrupt refusal to take Rexetin tablets can cause severe side effects, for this reason a gradual reduction in dosage up to the complete cessation of therapy is recommended.

special instructions

The use of an antidepressant should be started gradually with small doses, then increasing the dosage to obtain the necessary medical effect.

Drug therapy may trigger a relapse with manic mental disorder.

Hyponatremia is a common occurrence in older people who take Rexetine with other medicines.

Anxiety and fearPatients prone to depression during the course of therapy are often pursued by thoughts of suicide, they have a risk of suicide before the onset of remission. This condition may increase at the initial stage of recovery.

Patients suffering from concomitant disorders of the nervous system, during the entire course of treatment and prevention must be constantly monitored by a physician.

In clinical trials, no increase in the effect of alcohol was shown when used together with SSRIs Reksetin. But in any case, the use of alcoholic beverages is not recommended, as this may lead to exacerbations of the clinical picture, increase suicidal tendencies and provoke a lethal outcome.

In people suffering from renal and hepatic insufficiency, the concentration of paroxetine in the blood increases, which requires limiting the daily dosage of the active ingredient to 20 mg.

Drug interactions

With care, it is necessary to combine Rexetin with Tryptophan, Warfarin, Sumatriptan, tricyclic antidepressants, liver enzyme inhibitors, Zimetidine, Phenobarbital, Phenytoin, digoxin, DiazepamProcyclidine.

All these combinations can cause the appearance of unpleasant symptoms and cause disturbances in the work of various body systems.

It is forbidden to combine an antidepressant with drugs - MAO inhibitors.

Real experience

Opinion of practitioners and reviews of patients taking or taking the drug Rexetin, can be found in large numbers on the Internet.

Speaking of the drug Rexetin, it is worth noting that it is a potent antidepressant. For this reason, if you have mild depression, it is better to do without using this remedy. This medication is prescribed to patients who have been monitored for a long time and have been registered by a psychiatrist for more than one month. Suffering from severe nervous disorders and pursued suicidal intentions.

As a rule, light drugs do not help them. Remember, this drug in a pharmacy you just will not sell, and prescribe it yourself is not worth it. If it seems that taking antidepressants is necessary, contact a specialist first, you should not aggravate your condition by self-treatment.

Doctor - psychiatrist, Filatov Valentin Y.

Rexetine is a drug that has a strong effect on the central nervous system. This medication was created for the treatment of severe mental disorders. The drug has passed many clinical trials and has fully proven its effectiveness. In patients tested, a very persistent improvement and normalization of the condition was noted. There was a decrease in anxiety and panic, balance and concentration.

An important rule when taking medication is to comply with the recommendations of the doctor regarding the prescribed dosage and duration of administration. Do not ever change the prescribed instructions yourself - this is the most inadequate thing to do. Such actions can lead to serious consequences and aggravation of the disorders.

Doctor - psychotherapist Orlov Dmitry Anatolyevich

A few years ago, I had to go through a divorce, after which various symptoms began to appear. nervous breakdown.

Dizziness, panic attacks, palpitations, hypertension and anxiety. After many examinations, I turned to a psychiatrist.

The doctor quickly conducted a survey and diagnosed - endogenous depression, Rexetin wrote. Improvements appeared after 4 months of administration, then the dosage was reduced.

It is worth saying that I am still taking the drug for prophylaxis, but already in a small amount. Six months later, thanks to this drug, I felt completely healthy and vigorous.

Panova Ekaterina

As for me, Rexetin is an absolutely ineffective drug, the price is as much as 800 rubles, and the effect is almost zero, a different result was expected.

About two years ago, I had a severe depression. The doctor prescribed Rexetin on a tablet a day for three months. After a month of therapy, there was still no result.

After some time, thoughts of suicide were gone, longing and emptiness inside were replaced by simply indifference and lack of interest in life.

After this effect has ended, no further improvement has occurred. Plus, the reception was accompanied by numerous side effects, further complicating life. After the expiry of three months of treatment and the lack of results, I began to take another drug, at the same price, but the effect was already in a month.

Shagova Natalya

I lived peacefully, I didn’t really think about anything, when suddenly, at one unexpected moment, I had strange symptoms. The first attack happened in the middle of the night, a sharp jump in pressure, disarray in the head, heart like crazy, lack of oxygen. He called an ambulance, he thought everything, do not pump out.

It worked out, but later the attacks began to increase, and the diagnosis could not be made. After consulting a psychiatrist, Rexetine was prescribed treatment.

Having drunk the drug for half a year, I noticed that my condition returned to normal, I am very glad that everything was ok. Now I feel great and enjoy life.

Samarin Alexander

Purchase and selection of analogues

The price of the drug in Russia varies from 800 to 1000 rubles per pack. Store the drug should be at a temperature of 15 to 30 degrees Celsius. In the reach of children. Shelf life is 5 years.

Released strictly by prescription.

Similar means that, if necessary, you can replace Rexetine, are:Paxil

  • Adepress;
  • Paxil;
  • Aktaparoxetine;
  • Cyrestill;
  • Paroxetine;
  • Plizil.

As for the now popular antidepressant Paxil, it contains a larger number of active paroxetine component, so it is best to use it in cases of advanced depression, when Rexetin is low effective.